PROTRANS HLA Narcolepsy
Narcolepsy is a neurological disease which affects the ability of the brain to regulate
wake - sleep cycles and is often associated with e.g. cataplexy and sleep paralysis.
Genetically Narcolepsy has been described being the disease with the highest
HLA association worldwide. About 98% of the narcolepsy patients represent the
HLA DRB1*15:01 - DQB1*06:02-DQA1*01:02 haplotype (except African Americans)
with the allele HLA-DQB1*06:02 being the most significant marker.
As the Narcolepsy associated HLA alleles are present in 20% - 30% of the
general population the Protrans HLA Narcolepsy Domino System allows
either to exclude Narcolepsy or to give a further hint for investigation.
Frequencies of Alleles or Allele combinations with an association to Narcolepsy
HLA Associations according to published frequencies in Narcolepsy patients
HLA-DQB1*06:02
- 100% Caucasians
- 96% African Americans
- 55% of them being homozygous
- Homozygousity: strong predisposing effect in the range of
two to four times as compared to heterozygousity
HLA-DQB1*06:02 - DQA1*01:02
- Between 82% and 100%
HLA-DRB1*15:01 (or *15:03) - HLA-DQB1*06:02
- 98% Caucasians
- 60% African Americans
- 100% Koreans
DRB1*15:01 (or *15:03) - DQB1*06:02 - DQA1*01:02
- 95% Caucasians
- 75% African Americans
DRB1*15:01 (or *15:03)
- 100% Japanese
- 75% African Americans
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